Anion Exchangers

Anion Exchangers are a critical class of transmembrane proteins that primarily facilitate the exchange of anions, such as Cl^-, HCO₃^-, and SO₂^2-, between the intracellular and extracellular environment through the antiport mechanism. Anion Exchangers mainly include members of the solute carrier 4 (SLC4) and solute carrier 26 (SLC26) families, such as AE1 (SLC4A1), AE2 (SLC4A2), AE3 (SLC4A3), DRA (SLC26A3), and PAT1 (SLC26A6), which are widely distributed in tissues such as red blood cells, kidneys, and the digestive tract.
Anion Exchangers play a pivotal role in physiological processes such as maintaining acid-base balance, ion homeostasis, and metabolite excretion. Dysfunction of these proteins is closely associated with various diseases, including hereditary distal renal tubular acidosis, metabolic disorders, and abnormal regulation of the tumor microenvironment^[1]^[2].

References:

[1]. Alper SL. Molecular physiology of SLC4 anion exchangers. Exp Physiol. 2006 Jan;91(1):153-61. [Content Brief]

[2]. Mount DB, et al. The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch. 2004 Feb;447(5):710-21. [Content Brief]

Anion Exchangers Related Products (6):

By Effects:	Control (1) Inhibitor (1) Antagonists (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B1153

Glafenine	Antagonist	98.75%
Glafenine is a non-steroidal anti-inflammatory drug (NSAID) that can be used for pain relief research. Glafenine can also antagonize the misfolding of SLC4A11 protein.

HY-B1153A

Glafenine hydrochloride	Antagonist	99.25%
Glafenine hydrochloride is a non-narcotic analgesic and non-steroidal anti-inflammatory drug. It is an ABCG2 inhibitor with an IC₅₀ of 3.2 μM. Glafenine can also antagonize the misfolding of SLC4A11 protein.

HY-122671

OB-1	Inhibitor	99.12%
OB-1 is a stomatin-like protein-3 (STOML3) oligomerization blocker. OB-1 is an effective inhibitor of the self-association of Stomatin, STOML1 and STOML2, but not podocin.

HY-103703

DEAE Cross-linked dextran A 25
DEAE Cross-linked dextran A 25 is a weak anion exchanger.

HY-122671S

OB-1-d₃	Control
OB-1-d₃ is the deuterium labeled OB-1 (HY-122671). OB-1 is a stomatin-like protein-3 (STOML3) oligomerization blocker. OB-1 is an effective inhibitor of the self-association of Stomatin, STOML1 and STOML2, but not podocin.

HY-153812

AST 7062601
AST 7062601 (AST070) is a Ucp1 inducer that strongly induces endogenous Ucp1 expression in primary mouse brown adipocytes. Ucp1 refers to uncoupling protein, found in brown and beige fat cells. In mammals, UCP1 oxidizes fatty acids and uncouples ATP production in mitochondria to promote energy dissipation as heat. AST 7062601 can be used to study thermogenic, uncoupled respiration.

Name
Email *

	Sorry, but the email address you supplied was invalid.